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Other·Pre-Seed·

Houdini Bio

DNA sequence design infrastructure for durable genetic medicines

Category
Other
Launched
June 19, 2026
Stage
Pre-Seed
Founder
Jonathan Cohen-Gold
Website
houdinibio.com

Houdini Bio provides a platform for designing therapeutic DNA sequences that evade cellular silencing pathways. The company has discovered novel gene silencing mechanisms that shut down synthetic DNA introduced into cells. Using machine learning and first principles biology, Houdini Bio redesigns DNA to avoid these defenses while preserving therapeutic function. The result is DNA that achieves durable, high level expression at lower doses, improving safety and cost effectiveness.